The database of radiobiological parameters is a joint development of scientists of Tomsk Polytechnic University and specialists of the Radiotherapy Department of the Oncology Research Institute of Tomsk National Research Medical Center. It contains published data on research of tumors and normal tissues conducted in various laboratories and clinical centers. The database is designed to calculate radiobiological criteria based on an individual radiation therapy dosimetric plan, such as the probability of tumor control and the probability of complications in normal tissues.
To compile the database, our specialists conducted an extensive review of published studies on radiobiological characterization. While data for photon radiation therapy have been previously collected, this is the first time that data for neutron therapy have been systematized. The resulting database has several functionalities, including the storage of scientific and clinical data, quick information retrieval, and the ability to add, delete, and modify stored information. In addition, it can be constantly updated with new scientific discoveries and clinical results, providing up-to-date information to the medical community," says Eugenia Sukhikh, Director of the Technological Reference Center for Ionizing Radiation in Radiology, Radiation Therapy and Nuclear Medicine.
Scientists emphasize that the database is a multifunctional tool: in addition to clinical practice, it can be used in scientific research and in the educational process.
The reference center specialists also developed and registered a web application to work with this database. The software enables users to add, edit, and analyze complex scientific and clinical data for tumors and normal tissues. It is important that the data can be added and edited, including the details about its sources. In addition, the application allows to generate reports by specified parameters and export data. Another feature of the software is the ability for multiple users to work simultaneously.
"The web application helps quickly find information and make the necessary calculations. Importantly, models and parameters for calculating radiobiological criteria can be edited in the application. This makes it possible to improve the quality and efficiency of treatment of oncological diseases," says Ekaterina Selikhova, an engineer at the Technological Reference Center for Ionizing Radiation in Radiology, Radiotherapy and Nuclear Medicine.
In the future, scientists plan to expand the database toward neutron therapy. The updated database will make it possible to further improve the application.